{"id":273484,"date":"2026-08-17T12:00:44","date_gmt":"2026-08-17T12:00:44","guid":{"rendered":"https:\/\/invimed.pl\/?page_id=273484"},"modified":"2026-08-17T12:01:44","modified_gmt":"2026-08-17T12:01:44","slug":"pgt-sr","status":"publish","type":"page","link":"https:\/\/invimed.pl\/en\/badania\/badania-genetyczne\/zarodka\/pgt-sr","title":{"rendered":"PGT-SR \u2013 genetic testing of embryos for structural abnormalities"},"content":{"rendered":"<p class=\"wp-block-paragraph\">For some couples, difficulties in achieving or maintaining a pregnancy may be due to structural chromosomal changes in one of the partners. PGT-SR is a genetic test on embryos carried out during in vitro fertilisation treatment at Invimed, which helps to select the embryos with the greatest developmental potential. This makes it possible to reduce the risk associated with chromosomal abnormalities and support patients on their journey towards a healthy pregnancy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"czym%e2%80%afjest%e2%80%afbadanie%e2%80%afpgt-sr\">What is PGT-SR testing?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PGT-SR is a pre-implantation genetic test of embryos carried out during in vitro fertilisation. It is intended for patients who are carriers of balanced structural chromosomal changes, such as translocations and inversions. Although individuals who are carriers of such changes often have no apparent health symptoms, they may experience fertility problems, such as unexplained male infertility (e.g. low sperm count), implantation failures or recurrent miscarriages. PGT-SR enables the identification of embryos with a normal chromosome structure and the selection of those most likely to develop normally&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"czym-sa-aberracje-strukturalne-chromosomow-%e2%80%94-translokacje-inwersje\">What are structural chromosome aberrations \u2014 translocations and inversions?&nbsp;&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Let\u2019s imagine that our genome is like a library. Chromosomes are the shelves holding the books, and genes are the information written on their pages. Each book has its own specific place, which ensures that the whole library is well-organised and runs smoothly.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Chromosomal aberrations<\/strong> These are situations in which changes occur within this ordered system. If the number of shelves is greater or fewer than it should be, we refer to these as numerical aberrations. If the number of shelves remains the same but the arrangement of the information on them changes, we are dealing with structural aberrations. This group includes, amongst others, translocations and inversions.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Translocation<\/strong> This is a situation in which a book or part of a book is moved from one shelf to another. The amount of information remains the same; only its location changes.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Inversion<\/strong> It is like a situation where a section of a book is taken out, rotated by 180 degrees and placed back in the same spot. The information is still on the same shelf, but its orientation is reversed.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although individuals who are carriers of a translocation or inversion often have no health symptoms, these abnormalities can affect the reproductive process. Therefore, for patients who are carriers of such changes, pre-implantation genetic testing for chromosomal abnormalities (PGT-SR) can be carried out to help identify embryos with a normal genetic makeup.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"czym-rozni-sie-pgt-sr-od-pgt-a\">How does PGT-SR differ from PGT-A?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Both PGT-A and PGT-SR are genetic tests carried out on embryos during in vitro fertilisation. In both cases, the embryologist removes a few trophectoderm cells via biopsy and then sends the sample for genetic analysis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, each test has a slightly different purpose. PGT-A checks whether the embryo has the correct number of chromosomes. PGT-SR is carried out on patients who are carriers of a translocation or inversion; in addition to assessing the number of chromosomes, it also analyses abnormalities resulting from changes in their structure.<\/p>\n\n\n\n<section class=\"check-list\">\n\t    <header class=\"check-list__header\">\n        <div class=\"acf-innerblocks-container\">\n\n<h2 class=\"wp-block-heading\" id=\"wskazania-do-badania%c2%a0\">Indications for the test\u00a0<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">It is advisable to undergo PGT-SR pre-implantation testing when:\u00a0<\/p>\n\n<\/div>\n    <\/header>\n    <ul class=\"mb-0 p-0 check-list__inner\">\n            <li class=\"d-flex check-list__item\">\n            <div class=\"svg-container\">\n                <svg width=\"16\" height=\"16\">\n                    <use xlink:href=\"#icon-check-2\" \/>\n                <\/svg>\n            <\/div>\n            <div class=\"check-list__item__rte\">\n                <div class=\"check-list__item__rte\">\n<p><span data-contrast=\"auto\">A karyotype analysis revealed an abnormality in the structure of the chromosomes in one of the partners,<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<\/div>\n            <\/div>\n        <\/li>\n            <li class=\"d-flex check-list__item\">\n            <div class=\"svg-container\">\n                <svg width=\"16\" height=\"16\">\n                    <use xlink:href=\"#icon-check-2\" \/>\n                <\/svg>\n            <\/div>\n            <div class=\"check-list__item__rte\">\n                <p><span data-contrast=\"auto\">the couple had suffered recurrent miscarriages,<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n            <\/div>\n        <\/li>\n            <li class=\"d-flex check-list__item\">\n            <div class=\"svg-container\">\n                <svg width=\"16\" height=\"16\">\n                    <use xlink:href=\"#icon-check-2\" \/>\n                <\/svg>\n            <\/div>\n            <div class=\"check-list__item__rte\">\n                <p>previous embryo transfers had been unsuccessful,<\/p>\n            <\/div>\n        <\/li>\n            <li class=\"d-flex check-list__item\">\n            <div class=\"svg-container\">\n                <svg width=\"16\" height=\"16\">\n                    <use xlink:href=\"#icon-check-2\" \/>\n                <\/svg>\n            <\/div>\n            <div class=\"check-list__item__rte\">\n                <p>There has been a case in the family of a condition linked to changes in chromosome structure.<\/p>\n            <\/div>\n        <\/li>\n        <\/ul>\n<\/section>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"jak-przebiega-badanie\">How is the examination carried out?&nbsp;<\/h2>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-1&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-1-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-1\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Stage 1 Biopsy<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-1\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-1-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p class=\"wp-block-paragraph\">An embryo biopsy is usually carried out on day 5 of development, at the blastocyst stage. If, by day 5, the blastocyst is not sufficiently developed \u2013 particularly with regard to the trophectoderm cells \u2013 embryo biopsy may be carried out on day 6 or 7. An experienced embryologist collects several trophectoderm cells from the embryo. The collected material is then preserved and sent for genetic analysis. Embryos that have undergone PGT-SR testing are vitrified (frozen).\u00a0<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-2&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-2-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-2\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Stage 2: Genetic testing<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-2\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-2-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p class=\"wp-block-paragraph\">In the genetics laboratory, genetic material (DNA) is isolated from the embryo cells that have been collected and analysed using an NGS sequencer.\u00a0<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-3&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h3 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-3-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" data-wp-on--keydown=\"actions.handleKeyDown\" id=\"accordion-item-3\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">Stage 3. Embryo assessment<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h3>\n\n\n\n<div inert aria-labelledby=\"accordion-item-3\" data-wp-bind--inert=\"!state.isOpen\" id=\"accordion-item-3-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Once the results of the genetic test have been received, the doctor and the embryologist decide which of the genetically normal embryos are suitable for transfer. In appropriate cases, a genetic consultation is recommended.\u00a0<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-table\"><table style=\"border-style:dashed;border-width:3px\"><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\">IMPORTANT: Before commencing the procedure involving PGT-SR testing, the couple must provide the attending doctor with the karyotype results of the person who is a carrier of the structural chromosomal abnormality. This will enable the genetic analysis to be tailored to the couple\u2019s individual situation, or, if necessary, for additional tests to be commissioned in order to improve the accuracy of the results obtained.&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"ile-trwa-oczekiwanie-na-wynik\">How long does it take to get the result?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The results of a PGT-SR test are usually available within 2\u20133 weeks. In some cases, the waiting time may be slightly longer. It is advisable to confirm this timeframe with your doctor or embryologist.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"slowniczek-pojec\">Glossary of terms&nbsp;<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"translokacje\">Translocations<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><strong>Translocations<\/strong> <\/strong>\u2013 the transfer of genetic material between two different chromosomes.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"inwersje\"><strong>Inversions<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Inversions <\/strong>\u2013 the inversion of a chromosome segment within the same chromosome.<\/p>","protected":false},"excerpt":{"rendered":"<p>U cz\u0119\u015bci par trudno\u015bci z uzyskaniem lub utrzymaniem ci\u0105\u017cy mog\u0105 wynika\u0107 ze zmian strukturalnych chromosom\u00f3w wyst\u0119puj\u0105cych u jednego z partner\u00f3w. PGT-SR to badanie genetyczne zarodk\u00f3w wykonywane w trakcie leczenia metod\u0105 in vitro w Invimed, kt\u00f3re pomaga wybra\u0107 zarodki o najwi\u0119kszym potencjale rozwojowym. Dzi\u0119ki temu mo\u017cliwe jest ograniczenie ryzyka zwi\u0105zanego z nieprawid\u0142owo\u015bciami chromosomowymi i wsparcie pacjent\u00f3w [&hellip;]<\/p>\n","protected":false},"author":49,"featured_media":273485,"parent":269650,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-273484","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PGT-SR - badanie zarodka w kierunku translokacji - Invimed<\/title>\n<meta name=\"description\" content=\"PGT-SR wykrywa w zarodku zmiany strukturalne chromosom\u00f3w, np. translokacje. 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