{"id":3241,"date":"2024-04-18T12:14:50","date_gmt":"2024-04-18T12:14:50","guid":{"rendered":"https:\/\/invimed.pl\/?page_id=3241"},"modified":"2025-09-24T12:33:01","modified_gmt":"2025-09-24T12:33:01","slug":"hba-test","status":"publish","type":"page","link":"https:\/\/invimed.pl\/en\/test-hba","title":{"rendered":"HBA\u00ae test"},"content":{"rendered":"

The result of the test indicates what percentage of sperm is capable of fertilising the egg<\/strong><\/h2>\n\n\n\n

The HBA\u00ae test is a functional test that extends seminological diagnosis. It leads to the selection of an appropriate assisted reproduction technique, resulting in a higher probability of pregnancy. The HBA test determines the sperm's ability to bind to hyaluronate (hyaluronic acid) and thus determines the percentage of mature sperm that are capable of participating in fertilisation of the egg.<\/p>\n\n\n\n

What does the HBA\u00ae test investigate?<\/h2>\n\n\n\n

The primary purpose of the HBA\u00ae test is to determine the maturity of sperm in fresh semen. This is made possible by the binding of mature sperm to hyaluronan. HBA hyaluronate binding assay<\/em>, the hyaluronate binding test.<\/p>\n\n\n\n

The importance of hyaluronan in the fertilisation process<\/h3>\n\n\n\n
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  1. Hyaluronate is a substance that plays an important role in the interaction between the sperm and the egg cell. This interaction, if carried out correctly, leads to fertilisation. In nature, hyaluronate is found in the intercellular matrix of the ovarian thalamus surrounding the egg cell and is abundantly secreted by the granulosa cells of the thalamus.<\/li>\n\n\n\n
  2. In the final stage of spermatogenesis (the maturation process of the sperm), special spots develop on the surface of the sperm head which bind to hyaluronan and to the eggshell. The presence of these sites is essential for the fusion of the sperm head with the surface of the egg's zona pellucida during the fertilisation process taking place in the female reproductive tract.<\/li>\n\n\n\n
  3. Spermatozoa in which these sites have not developed on the surface are unable to bind to hyaluronate and are therefore unable to fuse with the surface of the oocyte's transparent envelope both under natural conditions and during in vitro fertilisation performed by the classic IVF method. Failure to bind to hyaluronate leads to non-fertilisation.<\/li>\n<\/ol>\n\n\n\n
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    When is the HBA test performed?<\/h2>\n\n\n\n

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    Indications for the HBA test<\/h3>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t