{"id":7089,"date":"2024-04-30T14:59:44","date_gmt":"2024-04-30T14:59:44","guid":{"rendered":"https:\/\/invimed.pl\/?page_id=7089"},"modified":"2025-12-12T12:08:16","modified_gmt":"2025-12-12T12:08:16","slug":"azf","status":"publish","type":"page","link":"https:\/\/invimed.pl\/en\/badania\/azf","title":{"rendered":"The AZF study, what is it?"},"content":{"rendered":"

Testing for microdeletions of the AZF region of the Y chromosome helps to determine the cause of male infertility. The fact that there are no sperm in the semen (azoospermia) or extremely few sperm (oligozoospermia) may be due to a mutation of the AZF region of the Y chromosome. Further treatment of the couple's infertility will also depend on the outcome of the test.<\/strong><\/p>\n\n\n\n

AZF and fertility <\/h2>\n\n\n\n

Examination of the AZF region involves genetic analysis of a region located on the long arm of the Y chromosome. Genes responsible for spermatogenesis, i.e. sperm production, are present there. The absence of one of these genes or its mutation is the cause of impaired spermatogenesis, which manifests itself in reduced sperm counts or a complete absence of sperm.<\/p>\n\n\n\n

\n\t
\n
\n\n

According to scientific studies, approximately 25% infertile men have microdeletions in the AZF region.                <\/p>\n\n\n\n

The AZF region is divided into three sub-regions: AZFa, AZFb, AZFc.<\/p>\n\n<\/div>\n <\/header>\n

    \n
  • \n
    \n \n \n <\/svg>\n <\/div>\n
    \n
    \n

    In the case of microdeletions in the AZFa subregion, the chances of obtaining spermatozoa during testicular biopsy are low; usually only Sertole cells, which are responsible for functions regulating spermatogenesis and nutrition, are then found,<\/p>\n<\/div>\n <\/div>\n <\/li>\n

  • \n
    \n \n \n <\/svg>\n <\/div>\n
    \n

    With AZFb microdeletions, the chance of obtaining sperm during a testicular biopsy is low,<\/p>\n <\/div>\n <\/li>\n

  • \n
    \n \n \n <\/svg>\n <\/div>\n
    \n

    The best chance of sperm being present at testicular biopsy is when there is an AZFc-type microdeletion - more than half of patients with this genetic defect undergo testicular biopsy successfully.<\/p>\n <\/div>\n <\/li>\n <\/ul>\n<\/section>\n\n\n\n

    Sperm obtained by biopsy are used for in vitro fertilisation by ICSI\/IMSI techniques or frozen for later use in assisted reproduction. The incidence of AZFa, AZFb and AZFc are respectively: 0.5-4%, 1-5% , 80%. Genetic alterations within the AZF region are passed on to male offspring.<\/strong><\/p>\n\n\n\n

    When to perform an AZF test<\/h2>\n\n\n\n

    If the semen test shows extreme oligozoospermia or azoospermia, the result should be consulted with an andrologist, who will recommend an AZF test if a genetic cause for such a semen test result is suspected.<\/p>\n\n\n\n

    How to prepare for the AZF study?<\/h2>\n\n\n\n

    You do not need to be specially prepared for the AZF genetic test. It does not require fasting or withdrawal from medication.<\/p>\n\n\n\n

    Where to perform the AZF test?<\/h2>\n\n\n\n

    The AZF test is performed at each Invimed clinic during the opening hours of the collection centre. You do not need to be registered to have an AZF test unless required by the clinic.<\/p>\n\n\n\n

    <\/p>","protected":false},"excerpt":{"rendered":"

    Badanie mikrodelecji regionu AZF chromosomu Y pomaga ustali\u0107 przyczyn\u0119 niep\u0142odno\u015bci m\u0119skiej. To, \u017ce w nasieniu nie ma plemnik\u00f3w (azoospermia) lub jest ich skrajnie ma\u0142o (oligozoospermia), mo\u017ce by\u0107 spowodowane mutacj\u0105 regionu AZF chromosomu Y. Od wyniku badania b\u0119dzie te\u017c zale\u017ca\u0142o dalsze leczenie niep\u0142odno\u015bci pary. AZF, a p\u0142odno\u015b\u0107  Badanie regionu AZF obejmuje genetyczn\u0105 analiz\u0119 regionu znajduj\u0105cego si\u0119 […]<\/p>\n","protected":false},"author":18,"featured_media":5563,"parent":847,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-7089","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nAZF: Badanie mutacji genowej chromosomu m\u0119skiego Y - Invimed<\/title>\n<meta name=\"description\" content=\"Badanie regionu AZF obejmuje genetyczn\u0105 analiz\u0119 regionu znajduj\u0105cego si\u0119 na d\u0142ugim ramieniu chromosomu Y.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AZF: Badanie mutacji genowej chromosomu m\u0119skiego Y - Invimed\" \/>\n<meta property=\"og:description\" content=\"Badanie regionu AZF obejmuje genetyczn\u0105 analiz\u0119 regionu znajduj\u0105cego si\u0119 na d\u0142ugim ramieniu chromosomu Y.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/invimed.pl\/en\/research\/azf\/\" \/>\n<meta property=\"og:site_name\" content=\"Invimed\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-12T12:08:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/invimed.pl\/wp-content\/uploads\/2024\/04\/1440x300-azf-jpg-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1440\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"AZF: Male Y chromosome gene mutation test - Invimed","description":"Examination of the AZF region involves genetic analysis of a region located on the long arm of the Y chromosome.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_GB","og_type":"article","og_title":"AZF: Badanie mutacji genowej chromosomu m\u0119skiego Y - Invimed","og_description":"Badanie regionu AZF obejmuje genetyczn\u0105 analiz\u0119 regionu znajduj\u0105cego si\u0119 na d\u0142ugim ramieniu chromosomu Y.","og_url":"https:\/\/invimed.pl\/en\/research\/azf\/","og_site_name":"Invimed","article_modified_time":"2025-12-12T12:08:16+00:00","og_image":[{"width":1440,"height":300,"url":"https:\/\/invimed.pl\/wp-content\/uploads\/2024\/04\/1440x300-azf-jpg-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimated reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/invimed.pl\/badania\/azf","url":"https:\/\/invimed.pl\/badania\/azf","name":"AZF: Male Y chromosome gene mutation test - Invimed","isPartOf":{"@id":"https:\/\/invimed.pl\/#website"},"primaryImageOfPage":{"@id":"https:\/\/invimed.pl\/badania\/azf#primaryimage"},"image":{"@id":"https:\/\/invimed.pl\/badania\/azf#primaryimage"},"thumbnailUrl":"https:\/\/invimed.pl\/wp-content\/uploads\/2024\/04\/1440x300-azf-jpg-1.jpg","datePublished":"2024-04-30T14:59:44+00:00","dateModified":"2025-12-12T12:08:16+00:00","description":"Examination of the AZF region involves genetic analysis of a region located on the long arm of the Y chromosome.","breadcrumb":{"@id":"https:\/\/invimed.pl\/badania\/azf#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/invimed.pl\/badania\/azf"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/invimed.pl\/badania\/azf#primaryimage","url":"https:\/\/invimed.pl\/wp-content\/uploads\/2024\/04\/1440x300-azf-jpg-1.jpg","contentUrl":"https:\/\/invimed.pl\/wp-content\/uploads\/2024\/04\/1440x300-azf-jpg-1.jpg","width":1440,"height":300},{"@type":"BreadcrumbList","@id":"https:\/\/invimed.pl\/badania\/azf#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Strona g\u0142\u00f3wna","item":"https:\/\/invimed.pl\/"},{"@type":"ListItem","position":2,"name":"Badania","item":"https:\/\/invimed.pl\/badania"},{"@type":"ListItem","position":3,"name":"Badanie AZF, co to jest?"}]},{"@type":"WebSite","@id":"https:\/\/invimed.pl\/#website","url":"https:\/\/invimed.pl\/","name":"Invimed","description":"Our mission is to create a happy family together","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/invimed.pl\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"}]}},"_links":{"self":[{"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/pages\/7089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/comments?post=7089"}],"version-history":[{"count":3,"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/pages\/7089\/revisions"}],"predecessor-version":[{"id":261829,"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/pages\/7089\/revisions\/261829"}],"up":[{"embeddable":true,"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/pages\/847"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/media\/5563"}],"wp:attachment":[{"href":"https:\/\/invimed.pl\/en\/wp-json\/wp\/v2\/media?parent=7089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}