Rodinia test - the key to a personalised infertility treatment pathway

Infertility is an increasingly common problem that affects many couples - often without an identifiable cause. In such cases, the Rodinia test comes to the rescue - a modern diagnostic tool that allows you to look deeper where traditional methods fail. This test identifies potential genetic disorders and assesses the risk of passing them on to future offspring. With it, you can discover the real source of your fertility problems and begin a treatment tailored to your unique needs.

Rhodinia - what is the study?

Rodinia analyses genetic mutations and chromosomal abnormalities that can make it difficult to get pregnant. This test not only detects the causes but, above all, opens the door to more effective treatment, based on knowledge rather than guesswork. For many patients, Rodinia becomes the beginning of a new, more informed path to parenthood.

Who is the Rodinia study for?

The Rodinia test is designed for individuals and couples who are struggling to get pregnant - regardless of the stage of diagnosis or treatment. This genetic test can add great value in situations where other methods do not provide clear answers.

Rodinia is particularly recommended for:

  • couples and people who are trying unsuccessfully to have a child,
  • women with irregular periods or lack of ovulation,
  • Men with reduced semen parameters (e.g. low sperm count),
  • individuals with suspected or diagnosed genetic disorders (e.g. syndromes associated with sex chromosome aneuploidy),
  • couples planning treatment with assisted reproduction methods,
  • candidates for egg or sperm donation,
  • people with a family history of infertility.

In addition, the thrombophilia panel and NAIT (non-immune neonatal thrombocytopaenia) test are recommended for women with recurrent miscarriages, pregnancy complications or thrombotic disorders.

Rodinia is a test that can help find the cause of a problem where other methods fail and open the way to more precise treatment.

Why choose the Rodinia test?

The Rodinia test includes three specialised genetic panels - for women, men and the thrombophilia and NAIT panel - allowing the precise analysis of the most common genetic causes of fertility problems.

Female infertility panel

Analyses 55 genes and X chromosome aneuploidies, including:

  • premature cessation of ovarian function (POI),
  • polycystic ovary syndrome (PCOS),
  • ovarian hyperstimulation syndrome (OHSS),
  • hypogonadotropic hypogonadism (including Kallmann syndrome).

Early identification of these disorders provides the opportunity to quickly implement appropriate measures - e.g. oocyte cryopreservation - to increase the chances of pregnancy in the future.

Male infertility panel

Includes 40 genes and aneuploidy analysis of X and Y chromosomes, including:

  • microdeletions of AZF regions in the Y chromosome (often associated with azoospermia),
  • endocrine disorders such as hypogonadotropic hypogonadism,
  • Kallmann syndrome and other genetic syndromes affecting fertility.

The test has prognostic value - in men with azoospermia, it can help to assess the chances of sperm recovery with TESE (testicular sperm retrieval) surgery.

Thrombophilia panel and NAIT

It analyses 22 genetic variants in 17 genes and is recommended for:

  • recurrent miscarriages,
  • thrombosis or a predisposition to it,
  • risk of neonatal alloimmune thrombocytopenia (NAIT).

The panel can be performed in addition to the female or male tests, or as a separate test.

Advantages of the Rodinia study

The Rodinia test is one of the most advanced genetic tests in infertility diagnosis. Through the use of advanced technology, it offers precise, reliable and clinically relevant information that can have a direct impact on the effectiveness of treatment.

Modern technology = high quality results

Rodinia uses advanced Target Capture Enrichment and next-generation sequencing (NGS), which allows for highly accurate analysis of genetic material. As a result, the study:

  • includes all coding regions of the genes included in the panel,
  • detects different types of mutations: SNVs (point changes), INDELs (small insertions/deletions), CNVs (larger copy number changes),
  • analyses X and Y chromosomes, including mosaicism with a sensitivity of up to 15% - which is particularly important in patients with azoospermia or atypical sexual development.

Benefits of the Rodinia study

The Rodinia test allows the early identification of genetic causes of fertility problems, which translates into a more accurate assessment of prognosis and a better tailored treatment pathway.

Individual approach to therapy

The test results help in the selection of appropriate assisted reproduction methods - such as TESE (testicular sperm retrieval), IVF (in vitro fertilisation) or ICSI (intra-cytoplasmic sperm injection).

Early intervention and fertility preservation

In women at risk of premature ovarian expiry (POI), the test allows a decision to cryopreserve oocytes before fertility deteriorates.

Support for the treatment of recurrent miscarriages and thrombotic disorders

By analysing the genetic variants associated with thrombophilia and NAIT, the test helps to select appropriate treatment (e.g. hormone therapy, anticoagulants) that can reduce the risk of complications in pregnancy.

Safety and comprehensiveness

The test is non-invasive and broad in scope. It covers both genes and sex chromosome variations, making Rodinia one of the most complete genetic tests available.

How to carry out the Rodinia test?

The Rodinia test is designed to be simple, safe and comfortable for the patient.

What are the steps in carrying out the Rodin test?

Choosing the right panel

Based on your medical history and clinical indications, the doctor selects the genetic panel that best suits your situation - e.g. female infertility panel, male infertility panel or thrombophilia and NAIT panel.

Sampling

The genetic material is obtained in a non-invasive way - by swabbing the inside of the cheek. The entire procedure is quick, painless and can be performed on site at the clinic.

Laboratory analysis

The collected sample is sent to the specialised Medicover Genetics laboratory, where it undergoes advanced genetic analysis using NGS (next-generation sequencing) technology.

Result and next steps

The test results are available within 2 to 4 weeks. Once they are received, your doctor will discuss with you the interpretation of the data and possible treatment and follow-up options.

How do I order a Rodinia test?

Rodinia testing is available at all Invimed clinics.

How do I sign up for research at Invimed?

- Use the helpline: call 500 900 888.

- Complete the online form: fill in the form on the clinic website.

- Go in person to one of the Invimed clinics.