I am after failed in vitro

Failed IVF is a serious blow to a couple who had high hopes for this complex and relatively expensive procedure. Although the in vitro fertilisation method has a high success rate, unforeseen difficulties and obstacles can arise at any stage of treatment. In most cases, these can be remedied.

What to do after failed IVF?

If you are wondering whether it is worth trying a second time, consult a specialist - preferably one who has experience of working with patients after unsuccessful IVF. At Invimed clinics, we have been helping couples in your situation for years - with great success.
As the causes of failed IVF can be both medical and embryological, all failed procedures are analysed by the attending doctor and the embryology team. By identifying the cause of failed IVF, we can choose the treatment method correctly and thus increase your chances of having a baby.

Many couples from all over Poland and abroad come to us. In the case of patients who have had unsuccessful IVF, the reasons for failure are the key to solving the problem, therefore in the clinics of Invimed we place great emphasis on diagnostics. We know what to focus on and what to look for, and - how to effectively help our patients to realise their dreams of having a child.

Robert Gizler, MD, Invimed Wrocław

Failed in vitro - why?

The most common causes of failure include:

  • Repeated implantation failures
  • Recurrent miscarriages
  • Poor response to hormonal stimulation
  • Abnormalities at the stage of fertilisation and embryo rearing

Repeated implantation failures

They concern 32% cases of failed IVF. The diagnosis occurs after a threefold failure of implantation in a situation where the embryos given were properly constructed and the uterus was prepared to receive them. A blood test shows a chorionic gonadotropin (hCG) level of zero 12-14 days after embryo transfer.

Failure at the level of embryo implantation may be related to the woman's age and the lower quality of the oocytes she has (ovarian follicles also age), reduced ovarian reserve or poor oocyte quality not due to the patient's advanced age.

Recommended diagnostic tests:

  • AMH,
  • InhibinB,
  • Cariotypes in both partners,
  • MSOME semen examination,
  • SCD HBA semen test,
  • Hysteroscopy with endometrial biopsy,
  • Ultrasound+SIS (ultrasound with contrast administered into the uterine cavity),
  • 3D ULTRASOUND,
  • immunological testing,
  • assessment of endometrial receptivity (ERA test).

If IVF has not resulted in a pregnancy, further management depends on the cause of the failure:

1 z 4

Repeated implantation failures

Repeated implantation failures

repeated implantation failures are an indication for causal treatment, including the use of drugs and treatments to promote endometrial growth, endometrial scratching, taking drugs to modify the immune response and preimplantation diagnosis of embryos; the method of treatment is selected individually, according to the patient's needs;

2 z 4

Recurrent miscarriages

Recurrent miscarriages

Recurrent miscarriages - depending on the cause of the miscarriages, causal treatment (removal of uterine lesions, correction of uterine cavity defects), immunomodulatory treatment (depending on indications), anticoagulants and supplementation of hormonal deficiencies are implemented;

3 z 4

Poor response to hormonal stimulation

Poor response to hormonal stimulation

It is advisable to individualise the administration of hormonal drugs, among other things by modifying their dosage, in addition to which an IVM procedure (maturation of oocytes under laboratory conditions prior to fertilisation), supplementation with appropriate drugs prior to hormonal stimulation or so-called mini IVF (in vitro in the course of a natural cycle or with minor stimulation) can be used;

4 z 4

Abnormalities at the stage of fertilisation or embryo rearing

Abnormalities at the stage of fertilisation or embryo rearing

abnormalities at the stage of fertilisation or embryo culture are an indication to undertake treatment of diagnosed conditions (endometriosis, systemic diseases and inflammatory conditions) before IVF, as well as lifestyle modifications and the use of supplements from the antioxidant group of drugs; at the stage of in vitro fertilisation, artificial activation of the oocyte is used; if the above measures are unsuccessful, the use of an oocyte or oocyte bank should be considered.

Failed IVF - when is the next one?

Just a few days after oocyte retrieval, more ovarian follicles appear in the ovaries, but we do not recommend renewing IVF immediately after a failed IVF.

For safety reasons, it is recommended that the interval between hormonal stimulation and ovarian punctures should be no less than a full two cycles.

I AM AFTER FAILED IN VITRO

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