ZyMōt ICSI and ZyMōt Multi - microfluidic devices for sperm selection
ZyMōt ICSI and ZyMōt Multi increase infertile couples' chances of obtaining normal embryos
ZyMōt ICSI, ZyMōt Multi (850 µL), ZyMōt Multi (3 mL) sperm selection chips are innovative sperm selection devices used in assisted reproductive techniques, developed by scientists from three universities in the United States. In Poland, they are successfully used in Invimed Infertility Treatment Clinics as part of optional procedures for in vitro fertilisation. The aforementioned chips have so far been called Fertile, Fertile Plus and Fertile Ultimate, hence the collective name Fertile Chips.
What is ZyMōt ICSI and ZyMōt Multi?
ZyMōt ICSI, ZyMōt Multi (850 µL), ZyMōt Multi (3 mL), collectively referred to so far as Fertile Chips, are specialised tools built to more effectively select the sperm that has the best chance of forming a healthy embryo. Each chip resembles a plate consisting of microscopic channels built on known hydrodynamic principles (microfluidics) that guide the interactions between the sperm and the surrounding microchannel structure.
This method - at the intersection of biology, physics, nanotechnology and engineering - allows the mapping of the sperm's behaviour during its natural journey through the female reproductive system. By using ZyMōt ICSI, ZyMōt Multi (850 µL), ZyMōt Multi (3 mL), the embryologist can select sperm of the highest quality and DNA integrity, thereby increasing the chances of obtaining normal embryos.
For whom are ZyMōt chips?
Only couples qualified for the procedure can benefit from sperm chip selection with ZyMōt ICSI, ZyMōt Multi (850 µL), ZyMōt Multi (3 mL) in vitro with ZyMōt chips by the attending physician. Therefore, if you want to use this method, ask your doctor at Invimed about it.
The use of sperm selection with the microfluidic device is particularly recommended for couples whose cause of infertility is related to the male factor. The manufacturer recommends this method for patients presenting with a moderate to moderately severe male factor problem, especially when dealing with:
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oligozoospermia (reduced sperm concentration),
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asthenozoospermia (abnormal and/or reduced sperm motility),
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teratozoospermia (abnormal sperm structure).
How does sperm selection affect the effectiveness of IVF?
The results of the Stanford University study showed that semen sorted using the ZyMōt microfluidic device not only has higher motility, but also has a significantly higher percentage of morphologically normal sperm with high DNA integrity and a lower percentage of reactive oxygen species.
Other studies have also shown an increase in the pregnancy rate with the first embryo transfer to 56%. This percentage is several percentage points higher than the percentage obtained in IVF procedures using standard sperm selection methods. This is possible because the percentage of highest quality embryos obtained is higher due to the use of ZyMōt chips. The embryos develop better and mostly implant, thus significantly increasing the chance of achieving a pregnancy.
Greater chance of IVF success
The results show that the use of ZyMōt chips increases the chances of infertile couples to obtain normal embryos. Sperm selection with ZyMōt ICSI, ZyMōt Multi (850 µL), ZyMōt Multi (3 mL) reduces the likelihood of genetic disorders (aneuploidy).
ZyMōt chips in Invimed clinics
ZyMōt ICSI, ZyMōt Multi (850 µL), ZyMōt Multi (3 mL) are among the techniques to increase the efficiency of in vitro. They were used for the first time in Poland in 2018, just in the Invimed network of infertility clinics (then called Fertile, Fertile Plus, Fertile Ultimate and appearing under the collective name Fertile Chip). Today, ZyMōt chips are available at all Invimed clinics and are used as assistive techniques for IVF procedures. The price for the application of sperm selection using the microfluidic method, depending on the clinic, ranges from PLN 600 to PLN 800.
| This innovative method can only be used by couples with appropriate medical indications, qualified by the attending physician. If you want to use this method, ask your doctor about it. |
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